V k with Gn,max, as the maximum conductance, V as the command potential, Vhalf as the voltage of half-maximal activation, and k as the slope factor. Two pulse protocols were used: This avoided dominance of IHCs contributing more sweeps. For extracellular recordings from individual SGNs, mice were anesthetized by i.
A variety of elements may be deficient in a person with CFS or related conditions, but the most common are Magnesium and Selenium. Low levels of each essential and non-essential element have a corresponding biochemical impact on the body.
The levels of these essential and trace elements can be determined by means of a Synaptic ribbon of hair cells mineral analysis. The vast majority of CFS sufferers have a number of the above elements in moderate to chronically low levels. In addition, a high toxic burden of heavy metals will have a displacement effect on specific nutritional elements, worsening the effect still for example, zinc.
Please see the toxic and nutritional element chart on the toxicity page for further information. Low magnesium and vitamin B6 levels are frequently associated with those suffering from sleep disorders.
Low zinc levels often indicated by a high hair mineral level are frequently associated with poor immune system function. Cobalt is derived from vitamin B12, and so a cobalt severe deficiency is often symptomatic of a severe B12 deficiency.
Poor digestive function, particurlarly low stomach acid and digestive enzyme production, as well as toxins on the inter- and intra-cellular membranes, may mean a person does not effectively absorb and extract all nutritional elements from consumed food and even supplements, for example magnesium, calcium and potassium and numerous trace elements.
Another effect of insufficient stomach acid and enzyme production is the inability to extract and absorb vital nutritional elements from food and even supplements, for example magnesium, calcium, zinc or potassium.
Magnesium is vital for normal muscle contraction and general functionbone health, maintenance of normal Synaptic ribbon of hair cells pressure and optimal cardiac healthand many enzymatic reactions.
It is critical to over different enzymes reactions in the body.
Magnesium is important in stabilising ATP. With a deficiency of Magnesium, the ATP becomes over-regulated or inhibited, resulting in low energy levels. In addition, inefficient amino acid conversion can result in a vast number of biochemical problems - as amino acids are involved in many processes.
Amino acids and the body's ability to break down protein and synthesise different amino acids including processes like methylation is essential in a huge number of bio-chemical processes in the body, besides building up tissue, including for example the synthesis of enzymes, hormones, neurotransmitters, antibodies, blood transport proteins and other vital types of protein; and in cellular energy production.
Enzymes protein-based are not just used in digestion but different enzymes play a huge number of different roles in the body, for example, breaking down inflammation or antioxidants. A failure to break down proteins properly in the digestive tract and a failure to convert specific amino acids properly in sufficient quantities clearly has a huge effect on the biochemical and hormonal balance, and functioning and efficiency of many processes in the body.
Specifically relating to nutrient depletion, besides poor digestive function, inefficient amino acid conversion can lead to the wasting of vital amino acids in the kidneys into the urine, for example, Taurine, which is required to effectively transport minerals into the tissues and cells.
Studies have shown that taurine levels in vegans are frequently significantly lower than in those eating meat and dairy products. Please see the Taurine section below and also Wikipedia for more information on Taurine.
Nutritional deficiences may also cause a number of adverse enegetic and biochemical effects in the body, including further impairment of the digestive system. It is usually not sufficient to suppplement additional minerals to overcome one's mineral deficiencies.
Chronic deficiencies should of course be addressed through immediate supplementation and this is something that a CFS sufferer should identify and establish at the very beginning of any treatment programme and using Betaine HCl to make up for the lack of stomach acid to help with digestion and extraction of the minerals and vitamins into the blood stream.
An article examining the beneficial effects of amino acid supplementation is shown at the link below. Treatment of Chronic Fatigue Syndrome with Specific Amino Acid Supplementation Identification of which amino acids are not being converted properly can be achieved by a blood or urinary amino acid profile.
Please see the Identification page for more information. However, until the digestive system is functioning properly, and the diet is sufficiently nutritious and appropriate for the individual, and the excessive amounts of toxins and partial detoxification products have been removed from the inter- and intra-cellular membranes, supplementation will only make so much progress.
And if neither the digestive system or mineral and vitamin deficiencies are addressed, it is likely that both will deteriorate further.
It is rather like a catch 22 situation. In addition, in some individuals, a very difficult to digest diet is likely to add to the above problems. As discussed above, stimulation of the digestive system energetically and removal of the vast majority of toxins from the body is necessary to enable the body to fully absorb all the minerals and vitamins it actually requires and is deficient in.
It is easy to see how many CFS cases remain unresolved if these both these areas are not addressed. As a general rule, chelated forms of nutritional elements e.
It is reputed that humate and fulvate salts of trace elements extracted from soil are highly effective delivery mechanisms for mineral supplementation and replacement as well as being excellent chelators please see the Fulvic and Humic acid section on the Detox page for more information.
However, this is not always true, depending on what element one is talking about and of course the individual i. Sometimes, a mixture of different forms of the same element may be optimal for absorption and delivery to the tissues.
An individual may be taking high levels of a particular metal supplement, e. I have personally found for Trace mineral elements that Picolinate is the optimal chelated form. · The synaptic ribbon is the key structural specialization of ribbon synapses.
Synaptic ribbons are large, electron-dense structures that immobilize numerous synaptic vesicles next to plombier-nemours.com · Innervation is important for ribbon regulation in mechanosensory hair cells. Mechanosensory hair cells of the lateral line are innervated by lateral line ganglion neurons that project afferent fibers to hair cells and octavolateralis efferent neurons that provide cholinergic input to hair plombier-nemours.com Ribbon synapse.
Ribbon synapses are sites of contact between neurons specialized for the rapid transmission of signals by the calcium-triggered secretion of neurotransmitter. The synaptic ribbon is a presynaptic electron-dense structure surrounded by neurotransmitter-filled vesicles and specialized for graded In hair cells, otoferlin plombier-nemours.com · The synaptic ribbon of hair cells is a large presynaptic organelle implicated in precise synaptic transmission of auditory information to afferent neurons.
Ribbon synapses are electron-dense bodies that vary in shape, size, and number across species, along the plombier-nemours.com Ribbon synapses of inner hair cells mediate high rates of synchronous exocytosis to indefatigably track the stimulating sound with sub-millisecond precision.
The sophisticated molecular machinery of the inner hair cell active zone realizes this impressive performance by enabling a large number of synaptic voltage-gated CaV Ca2+-channels, their tight coupling to synaptic vesicles and fast plombier-nemours.com · Because synaptic release by saccular hair cells peaks at specific frequencies (Rutherford and Roberts, ), the release of neurotransmitter by hair cells might provide an additional degree of tuning.
We have therefore investigated the frequency responsiveness of synapses in a tonotopically organized auditory organ, the bullfrog's amphibian plombier-nemours.com